4-Hydroxypyrazolo (3,4-d) Pyrimidine (HPP) in the Treatment of Gout: Preliminary Observations
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منابع مشابه
4-hydroxypyrazolo (3,4-d) Pyrimidine (hpp) in the Treatment of Gout: Preliminary Observations.
4-hydroxypyrazolo (3,4-d) pyrimidine (B.W. 56-158: HPP) is a potent inhibitor of the enzyme xanthine oxidase. It was first used in the treatment of leukaemia to suppress the oxidation of 6-mercaptopurine to the therapeutically inert metabolite 6-thiouric acid, and the observation that it lowered the concentration of uric acid in serum and urine has led to its use in gout (Rundles, Wyngaarden, H...
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Some studies on the effects of xanthine oxidase inhibitor allopurinol [4-hydroxypyrazolo(3,4-d)pyrimidine] on allantoin metabolism of soybean plants (Glycine max cv. Tamanishiki) are reported. Soybean seedlings, aseptically germinated for 96 hours on agar containing 1 millimolar allopurinol, contained only slight amounts of allantoin, allantoic acid, and urea as compared with controls. Analysis...
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The pyrazolo-[3,4-d]pyrimidine ring system of the title compound, C12H10N4S, is essentially planar [maximum deviation = 0.025 (1) Å for the C atom bearing the S atom] and almost perpendicular to the phenyl ring [dihedral angle = 71.42 (6)°]. In the crystal, mol-ecules are linked via pairs of N-H⋯N hydrogen bonds, forming inversion dimers.
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The title compound, C(6)H(4)ClN(3), is essentially planar with the pyrrole and pyrimidine rings inclined to one another by 0.79 (15)°. In the crystal, mol-ecules are connected via pairs of N-H⋯N hydrogen bonds, forming inversion dimers. These dimers are linked via C-H⋯N inter-actions, forming a two-dimensional network parallel to (10-1).
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1964
ISSN: 0003-4967
DOI: 10.1136/ard.23.6.439